RESEARCH LINES

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Bone metabolism and regeneration

• Cellular interactions in bone regenerative strategies

• Pharmacological approaches for the enhancement of bone regeneration

• Biological response to biomaterials and medical devices for bone tissue applications

• Modulation of the bone metabolism in systemically compromised conditions

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Regeneration of soft and hard oral tissues

• Cellular interactions at the mucosa, periodontal ligament and alveolar bone tissues

• Modulation of the oral tissues regeneration

• Biological evaluation of dental materials/devices

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Cytotoxicity and biocompatibility

• Toxicity screening assays of potentially bioactive molecules

• Biocompatibility evaluation of devices and materials envisaged to interact with biological systems

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MODELS

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In vitro models - monoculcures, co-cultures, 3D-culture systems

• Cell culture models for bone metabolism and regeneration (human, rodents)

  • Mesenchymal stem cells; osteoblastic cells; osteoclast precursor cells; osteoclastic cells; endothelial cells

• Cell culture models for regeneration of soft and hard oral tissues (human, rodents)

  • Gingival fibroblasts; periodontal ligament cells; alveolar bone cells; epithelial cells; keratinocytes

• Variety of cell lines for cytotoxicity and drug screening assays

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Ex vivo models

• Chick Chorioallantoic Membrane (CAM) assay​

• Neonatal rat calvaria organotypic culture

• Chicken embryo femur organotypic culture

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In vivo models - laboratory animals studies on rodents and rabbits

• Subcutaneous and intramuscular implantation

• Bone tissue healing at calvaria, mandible, tibia and femur

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SCIENTIFIC NETWORKING

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Map graph displaying the geographic location of Bonelab's research collaborations.