© 2019 by Bone Lab

Research

RESEARCH LINES
Bone metabolism and regeneration
  • Cellular interactions in bone regenerative strategies

  • Pharmacological approaches for the enhancement of bone regeneration

  • Biological response to biomaterials and medical devices for bone tissue applications

  • Modulation of the bone metabolism in systemically compromised conditions

Regeneration of soft and hard oral tissues
  • Cellular interactions at the mucosa, periodontal ligament and alveolar bone tissues
  • Modulation of the oral tissues regeneration
  • Biological evaluation of dental materials/devices
Cytotoxicity and biocompatibility
  • Toxicity screening assays of potentially bioactive molecules

  • Biocompatibility evaluation of devices and materials envisaged to interact with biological systems

MODELS

In vitro models - monoculcures, co-cultures, 3D-culture systems
  • Cell culture models for bone metabolism and regeneration (human, rodents)

    • Mesenchymal stem cells; osteoblastic cells; osteoclast precursor cells; osteoclastic cells; endothelial cells

  • Cell culture models for regeneration of soft and hard oral tissues (human, rodents)

    • Gingival fibroblasts; periodontal ligament cells; alveolar bone cells; epithelial cells; keratinocytes

  • Variety of cell lines for cytotoxicity and drug screening assays

Ex vivo models
  • Chick Chorioallantoic Membrane (CAM) assay​

  • Neonatal rat calvaria organotypic culture

  • Chicken embryo femur organotypic culture

In vivo models - laboratory animals studies on rodents and rabbits
  • Subcutaneous and intramuscular implantation

  • Bone tissue healing at calvaria, mandible, tibia and femur

SCIENTIFIC NETWORKING

Map graph displaying the geographic location of Bonelab's research collaborations. 

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